Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging
Popovich, I. G., Zabezhinski, M. A., Anisimov, V. N., Kovalenko, A. L., Petrov, A. Y., Semenchenko, A. V.
, Yashin, A. I.
Bulletin of experimental biology and medicine, 136:6, 595–598 (2003)
Treatment of female SAMP-1 mice with Neuronol (drug containing succinic acid) given with drinking water starting from the age of 2 months during the whole life prolonged the lifespan and markedly reduced mortality of animals aged 1.5-2 years. Neuronol inhibited the development of spontaneous tumors, primarily lymphomas, and significantly prolonged lifespan in mice with tumors. Long-term treatment with Neuronol had no pathological side effects. Our experiments demonstrated geroprotective and anticarcinogenic activity of Neuronol and safety of its long-term use.