Journal Article
Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumor incidence in female CBA mice
Anisimov, V. N., Khavinson, V. K., Michalski, A. I., Yashin, A. I.
Mechanisms of Ageing and Development, 122:1, 41–68 (2001)
Abstract
Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys¯Glu or with synthetic pineal tetrapeptide
Ala¯Glu¯Asp¯Gly both in a single dose of 0.1 g/animal monthly for five consecutive days from the age of 6 months until natural death. Lys¯Glu did not
significantly influence the body weight and food consumption, free radical processes and estrus function in mice and did increase their physical activity with the
subsequent decrease in spontaneous lung adenomas incidence. The pineal peptide treatment was failed to modify the food consumption and physical strength
of mice, and was followed by the increase in the body weight, mean survival (by 5.3%, P < 0.05) and maximum (by 10 months), by slow down of the ageing
of estrus function, by the decrease in body temperature, physical activity, free radical processes and spontaneous tumor incidence (mainly, lung adenomas) in
mice. These data suggest the geroprotector potential of the pineal peptide. (© ELSEVIER SCIENCE IRELAND LTD.)