Regulation of longevity and stress resistance by Sch9 in yeast

Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., Longo, V. D.
Science, 292:5515, 288–290 (2001)


The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis elegans. We screened for long-lived mutants in nondividing yeast Saccharomyces cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 were required for this life-span extension. These results indicate that longevity is associated with increased investment in maintenance and show that highly conserved genes play similar roles in life-span regulation in S. cerevisiae and higher eukaryotes. (© 2001 BY THE AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE)
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